Cholesterol and Kir channels
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چکیده
منابع مشابه
Mechanism of Inward Rectification in Kir Channels
Two recent papers published in the Journal of General Physiology (Guo and Lu, 2003; Guo et al., 2003) address the mechanism of inward rectification by polyamines in Kir2.1 channels. In these two papers, Guo et al. (2003) extensively analyze channel block by monoamines, diamines (DAs), and polyamines of varying length and charge, using thermodynamic mutant cycles to calculate interaction energie...
متن کاملRegulation of Kir Channels by Intracellular pH and Extracellular K+
ROMK channels are regulated by internal pH (pH(i)) and extracellular K(+) (K(+)(o)). The mechanisms underlying this regulation were studied in these channels after expression in Xenopus oocytes. Replacement of the COOH-terminal portion of ROMK2 (Kir1.1b) with the corresponding region of the pH-insensitive channel IRK1 (Kir 2.1) produced a chimeric channel (termed C13) with enhanced sensitivity ...
متن کاملVascular regulation via KIR channels and Na(+)/K(+)-ATPase.
Follow this and additional works at: http://ecommons.udayton.edu/hss_fac_pub Part of the Biomechanics Commons, Cardiovascular System Commons, Exercise Physiology Commons, Exercise Science Commons, Leisure Studies Commons, Motor Control Commons, Musculoskeletal System Commons, Occupational Therapy Commons, Other Kinesiology Commons, Other Rehabilitation and Therapy Commons, Physical Therapy Comm...
متن کاملSpermine Is Fit to Block Inward Rectifier (Kir) Channels
Molecular biology has shown there to be a great diversity of potassium channel isoforms. Among the simplest structurally are the inward rectifier potassium channel, KCNJ gene family. These channels are open in the region of the resting potential, a potential that they therefore help to determine. Some 14 genes are known for this family, classified into 7 subfamilies in terms of sequence homolog...
متن کاملLipids driving protein structure? Evolutionary adaptations in Kir channels.
Many eukaryotic channels, transporters and receptors are activated by phosphatidyl inositol bisphosphate (PIP(2)) in the membrane, and every member of the eukaryotic inward rectifier potassium (Kir) channel family requires membrane PIP(2) for activity. In contrast, a bacterial homolog (KirBac1.1) is specifically inhibited by PIP(2). We speculate that a key evolutionary adaptation in eukaryotic ...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2009
ISSN: 1521-6543,1521-6551
DOI: 10.1002/iub.192